1.0Avalere Health Advisoryhttps://advisory.avalerehealth.comrich600338<blockquote class="wp-embedded-content" data-secret="XEOeExosCy"><a href="https://advisory.avalerehealth.com/insights/variability-of-comparator-drugs-in-ex-us-htas-offers-lessons-for-the-ira">Variability of Comparator Drugs in Ex-US HTAs Offers Lessons for the IRA</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://advisory.avalerehealth.com/insights/variability-of-comparator-drugs-in-ex-us-htas-offers-lessons-for-the-ira/embed#?secret=XEOeExosCy" width="600" height="338" title="“Variability of Comparator Drugs in Ex-US HTAs Offers Lessons for the IRA” — Avalere Health Advisory" data-secret="XEOeExosCy" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); </script> https://advisory.avalerehealth.com/wp-content/uploads/2022/09/27279-1-MichaelCiarametaro-400x600-1.jpg600400As a key component of the Medicare Drug Price Negotiation Program under the Inflation Reduction Act (IRA), the Centers for Medicare and Medicaid Services (CMS) compares products under negotiation with therapeutic alternatives to establish comparative benchmarks for safety, effectiveness, and cost. Across the globe, health technology assessment (HTA) bodies use comparative processes to inform decisions…